Mast Cells in Abnormal Uterine Bleeding

Abnormal uterine bleeding is one of the commonest disorder in the female, which needs thorough investigation to ascertain the exact aetiological basis so that a proper treatment can be rendered to such cases. Rumbolz and Greene (1957) studied mast cells in the endometrium in different physiological and pathological conditions and observed definite increase of mast cells in the secretory phase, decidua of pregnancy and certain cases of dysfunctional uterine bleeding associated with the secretory endometrium. Similar observations were also made by Saigal and Balasubramanyan (1963) in patients with dysfunctional uterine bleeding with secretory endometrium as well as in patients after abortion. But Mehra et al (1970) in their study found no definite relationship of mast cell count in the endometrium with dysfunctional uterine bleeding, except in those cases following complete or incomplete abortion. From these observations, it was suggested that presence of metachromatic granules of the mast cells in the endometrimn serve as the ready source of locally available heparin which mixes with the menstrual blood and produces free